Baum lab
How do malaria parasites move? Over the last 5+ yrs our lab has been working with the great teams of Kathy Trybus (University of Vermont) and Anne Houdusse (Institut Curie) to define the components of the motor https://doi.org/10.1074/jbc.M117.813972, provide a first glimpse of its structure https://doi.org/10.1038/s41467-019-11120-0, then complete it https://doi.org/10.7554/eLife.60581, and now finally (just out) drug it https://doi.org/10.7554/eLife.60581!
Led by Dr Kenny Malpartida-Cardenas, working with the amazing teams of Pantelis Georgiou, Jesus Rodriguez-Manzano & Aubrey Cunnington at Imperial College London, we are (with each paper) one step closer to a point-of-care digital diagnostic for malaria....
Confocal microscopy imaging of the Anopheles mosquito midgut. Labeled with DAPI (grey nuclei) and Phalloidin (actin, red). From Angrisano et al (2012) IJP.
How do malaria parasites move? Over the last 5+ yrs our lab has been working with the great teams of Kathy Trybus (University of Vermont) and Anne Houdusse (Institut Curie) to define the components of the motor https://doi.org/10.1074/jbc.M117.813972, provide a first glimpse of its structure https://doi.org/10.1038/s41467-019-11120-0, then complete it https://doi.org/10.7554/eLife.60581, and now finally (just out) drug it https://doi.org/10.7554/eLife.60581!