The Baum lab has a wide range of interests covering every scale of biology and every stage of the malaria parasite lifecycle. This includes projects from: atomic level protein structure, targeted gene disruption using CRISPR/Cas9, through to single molecule imaging and biophysics; sub-cellular level including super resolution imaging and live imaging of motile malaria parasites in multi-colour 4D; and the whole cell, imaging parasites on the move. Our interests incorporate focuses from host-cell invasion through to mosquito colonisation, liver-to-blood infection and the process of sexual stage development. We're passionate about drug discovery and diagnostics, working with collaborators. Our primary focus right now is on walking the walk of a new malaria vaccine - watch this space! Ultimately, our eclectic interests all centre on the fundamentals of parasite cellular biology. We are best defined by the interests and amazing unique skills of each researcher in the lab; each bringing their own style towards a holistic understanding of parasite biology and development of strategies to stop malaria disease.
Lab Head: Although my research career has covered many wide areas of interests, I have had a long-standing fascination with the processes of erythrocyte invasion and the generic mechanisms that define cell motility/invasion. I am also passionate about drug discovery and translation.
Postdoctoral scientist: Josh is keen on developing new tools to study parasite-host interactions, with key expertise in liver-stage infection and sporozoite biology
Postdoctoral Scientist: Farah is a recent recruit to the transmission team with a background in mosquito-parasite-microbiome interactions. She is exploring transmission and drug resistance.
Laboratory Manager and now PhD student: Fabio is a master protein chemist and laboratory manager for the Baum lab with a hand in pretty much every project! He is working on targeting protein complexes for his PhD.
Postdoctoral scientist: Alisje leads our MMV-sponsored programme finding drugs targeting parasite transmission through the mosquito.
Postdoctoral Scientist: Mo joins the team, with a background in immunology to explore comparative host immune responses to different malaria vaccines strategies.
Insectary Manager: Mark is the backbone of the transmission work in the lab, looking after the Anopheles stephensi colony and ensuring the critters are fit and well for Plasmodium transmission!
Research Technician: Joining us in 2020 from Australia, Dave is working on the MMV program and bringing his skills in immunology to the vaccine program.
Postdoctoral Scientist: Blazing a trail in transmission, Eliana is focussed on dissecting sporozoite biology and the power of single cell RNA sequencing.
Postdoctoral scientist: Jointly with the lab of Molly Stevens, based in the Dept of Engineering at Imperial, Adrian is a Sir Henry Wellcome Postdoctoral Fellow working at the interface between nano-vesicles and parasite biology.
Research Technician: MMV/Gates technician coming soon....
Emeritus Professor and legend in the field of clinical malaria, pathogenesis and red cell invasion with a particular interest in the still unresolved question of why children actually die from malaria...
Emeritus Professor and legend in the field of malaria transmission biology with expertise in genetic crosses, linkage group selection and gametocyte biology.
Postgraduate (Masters), Undegraduate students and Visitors
Ms Shubha Talwar (MRES) 2020; Ms Carmen Rodriguez (MRES) 2020.
Past lab members and visitors
Ms Mira Davidson (Technician) 2020; Dr Thomas Blake (PhD) 2020; Dr George Ashdown (Postdoc) 2020; Ms Emmanuoela Petsolari (MSc) 2020; Mr Jingran Zhuo (MRES) 2020; Ms Nina Short (MSc) 2020; Ms Marine Secchi (MRES) 2020; Ms Josephine Eum (MRES) 2020; Dr Silvia Haase (Postdoc) 2019; Dr Kathrin Witmer (Postdoc) 2019; Ms Karolina Oniszczuk (Technician) 2019; Ms Sarah Jordan (MSc) 2019; Mr Adam Efrat (MSc) 2019; Ms Irene Garcia Barbazan (Technician) 2019; Dr Kate Wright (Postdoc) 2019; Mr Fernando Sanchez-Roman Teran (Technician) 2019; Ms Linda Makhlouf (Technician) 2019; Ms Pantki Vaishnav (MSc) 2019; Dr Oriol Llora (PhD) 2019; Mr Oriol Llora (Visitor) 2019; Ms Evelyn Quansah (Visitor); Mr Brian Leung (MRES) 2018; Dr Oliver Lyth (PhD) 2018; Ms Emily Calamita (MSc) 2018; Ms Maddy Wynn (MSc) 2018; Ms Houriiyah Tegally (MSc) 2018; Dr Michael Delves (PDRA) 2018; Dr Marion Koch (PhD graduate) 2018; Ms Ursula Straschil (Technician and Laboratory Manager) 2018; Ms Dounia Cherkoui (Technician and MRES) 2018; Mr Tariq Shour (MSc) 2018; Ms Abigail Laverack (MRES) 2018; Mr Toby Barnes (MRES) 2017; Ms Eva Hamrud (MSc) 2017; Ms Dounia Cherkoui (MSc) 2017; Dr Holly Matthews (Postdoc) 2017; Ms. Celia Miguel Blanco (Technician) 2017; Ms. Olivia Swann (Technician) 2017; Mr. Max Addison (MRES) 2017; Ms. Xenia Karlsson (MSc) 2016; Ms. Sara Zakutansky (RT) 2016; Ms. Katja Hassler (Medical Student Visitor) 2016; Dr. Hella Baumann (Postdoc) 2016; Ms. Linda Makhlouf (MSc) 2016; Ms. Olivia Swann (MSc) 2016; Dr. Rama McCrorie (Postdoc) 2016; Dr. Andrea Ruecker (Postdoc) 2016; Dr. Chwen Tay (Postdoc) 2016; Ms. Eloise Withnell (Undergrad) 2016; Ms. Janice Tong (Undergrad) 2016; Mr. Dominic Raffin (Undergrad) 2016; Mr. Matthew Sinnott (Undergrad) 2016; Mr. Vladimir Chapman (Undergrad) 2016; Mr. David Busse (MSc) 2016; Ms. Mengqiao Li (MSc) 2016; Mr. Hossain Delowar (MSc) 2016; Dr. Sara Rute Lamas Oliveira Marques (Postdoc) 2016; Mr. Niklas Rehmert (MSc) 2015; Ms. Desiree Eggers (MSc) 2015; Mr Jonathan Mitchell (MSc) 2015; Dr. Alexandre Dufour (Visitor - Pasteur Institute) 2014; Dr. Maya Olshina (PhD) 2014; Dr. Liz Zuccala (PhD) 2014; Dr. Fiona Angrisano (PhD) 2014; Ms. Rachel Gillespie (MSc) 2014; Ms. Josie Ferreira (MSc) 2014; Mr. Javier Vinals Camallonga (MSc) 2014; Dr. Silvia Haase (Postdoc) 2014; Dr. Wilson Wong (Postdoc) 2014; Ms. Melanie Condron (Technician) 2014; Ms. Yan Hong Tan (Research Technician) 2014; Mr. Raphael Kim (Technician) 2014; Ms. Melanie Stockhausen (MSc) 2014; Ms. Grace Singh (Undergrad) 2014; Dr. Noa Dahan Pasternak (Visitor) 2013; Dr. Tim Satchwell (Visitor) 2013; Dr. Mark Scott (Visitor) 2013; Dr. Kartik Bane (Visitor) 2012; Dr. Ito Daisuke (Visitor) 2012; Dr. David Riglar (PhD) 2012; Mr. Danushka Marapana (Technician) 2012.