The Baum lab has a wide range of interests covering every scale of biology and every stage of the malaria parasite lifecycle. This includes projects from: atomic level understanding of protein structure, targeted gene disruption using CRISPR/Cas9, through to single molecule imaging and biophysics; sub-cellular level including super resolution imaging and live imaging of motile malaria parasites in multi-colour 4D; and the whole cell, imaging parasites on the move. Our interests incorporate focuses from host-cell invasion, protein translation and refolding, through to mosquito colonisation, liver-to-blood infection and the process of sexual stage development as well as developing strategies to target each either as new drug targets or the basis for new combination vaccines. Ultimately, our eclectic interests all centre on the fundamentals of parasite cellular biology. We are best defined by the interests and amazing unique skills of each researcher in the lab; each bringing their own style towards a holistic understanding of parasite biology and development of strategies to stop malaria disease.
Lab Head: Although my research career has covered many wide areas of interests, I have had a long-standing fascination with the processes of erythrocyte invasion and the generic mechanisms that define cell motility/invasion. I am also passionate about drug discovery and translation.
Postdoctoral scientist: George specializes in applying advanced imaging methods to capture nanoscale organisation and live-cell dynamics of molecular events. His work is using analysis to quantify these events to understand malaria invasion among other concepts.
Postdoctoral scientist: Josh is keen on developing new tools to study parasite-host interactions, with key expertise in liver-stage infection and sporozoite biology
Laboratory Manager and now PhD student: Fabio is a master protein chemist and laboratory manager for the Baum lab with a hand in pretty much every project! He is working on targeting protein complexes for his PhD.
Research Technician: After completing her PhD in South Africa, Alisje has joined the lab to drive our MMV-sponsored programme finding drugs targeting parasite transmission through the mosquito.
Postdoctoral Scientist: Farah is a recent recruit to the transmission team with a background in mosquito-parasite-microbiome interactions. She is exploring transmission and drug resistance.
PhD student (ICB CDT): A final year PhD student exploring protein chemistry in particular of actin regulators and folding in parasites and beyond.
Postdoctoral scientist: Jointly with the lab of Molly Stevens, based in the Dept of Engineering at Imperial, Adrian is a Sir Henry Wellcome Postdoctoral Fellow working at the interface between nano-vesicles and parasite biology.
Postdoctoral Scientist: Part of the new team blazing a trail in transmission, Eliana is focussed on dissecting the liver stages of parasite invasion and development.
PhD student: A final year PhD student Interested in the role of the actomyosin cytoskeleton in the parasite life cycle.
Research Technician: Sarah is a recently completed MRES student with a passion for imaging working on parasite sexual development in the mosquito.
Emeritus Professor and legend in the field of malaria parasite biology with a particular interest in the role of erythrocyte antigens in asexual parasite infection.
Postgraduate (Masters), Undegraduate students and Visitors
Ms Nina Short (MSc); Ms Marine Secchi (MRES); Ms Josephine Eum (MRES)
Past lab members and visitors
Dr Silvia Haase (Postdoc) 2019; Dr Kathrin Witmer (Postdoc) 2019; Ms Karolina Oniszczuk (Technician) 2019; Ms Sarah Jordan (MSc) 2019; Mr Adam Efrat (MSc) 2019; Ms Irene Garcia Barbazan (Technician) 2019; Dr Kate Wright (Postdoc) 2019; Mr Fernando Sanchez-Roman Teran (Technician) 2019; Ms Linda Makhlouf (Technician) 2019; Ms Pantki Vaishnav (MSc) 2019; Dr Oriol Llora (PhD) 2019; Mr Oriol Llora (Visitor) 2019; Ms Evelyn Quansah (Visitor); Mr Brian Leung (MRES) 2018; Dr Oliver Lyth (PhD) 2018; Ms Emily Calamita (MSc) 2018; Ms Maddy Wynn (MSc) 2018; Ms Houriiyah Tegally (MSc) 2018; Dr Michael Delves (PDRA) 2018; Dr Marion Koch (PhD graduate) 2018; Ms Ursula Straschil (Technician and Laboratory Manager) 2018; Ms Dounia Cherkoui (Technician and MRES) 2018; Mr Tariq Shour (MSc) 2018; Ms Abigail Laverack (MRES) 2018; Mr Toby Barnes (MRES) 2017; Ms Eva Hamrud (MSc) 2017; Ms Dounia Cherkoui (MSc) 2017; Dr Holly Matthews (Postdoc) 2017; Ms. Celia Miguel Blanco (Technician) 2017; Ms. Olivia Swann (Technician) 2017; Mr. Max Addison (MRES) 2017; Ms. Xenia Karlsson (MSc) 2016; Ms. Sara Zakutansky (RT) 2016; Ms. Katja Hassler (Medical Student Visitor) 2016; Dr. Hella Baumann (Postdoc) 2016; Ms. Linda Makhlouf (MSc) 2016; Ms. Olivia Swann (MSc) 2016; Dr. Rama McCrorie (Postdoc) 2016; Dr. Andrea Ruecker (Postdoc) 2016; Dr. Chwen Tay (Postdoc) 2016; Ms. Eloise Withnell (Undergrad) 2016; Ms. Janice Tong (Undergrad) 2016; Mr. Dominic Raffin (Undergrad) 2016; Mr. Matthew Sinnott (Undergrad) 2016; Mr. Vladimir Chapman (Undergrad) 2016; Mr. David Busse (MSc) 2016; Ms. Mengqiao Li (MSc) 2016; Mr. Hossain Delowar (MSc) 2016; Dr. Sara Rute Lamas Oliveira Marques (Postdoc) 2016; Mr. Niklas Rehmert (MSc) 2015; Ms. Desiree Eggers (MSc) 2015; Mr Jonathan Mitchell (MSc) 2015; Dr. Alexandre Dufour (Visitor - Pasteur Institute) 2014; Dr. Maya Olshina (PhD) 2014; Dr. Liz Zuccala (PhD) 2014; Dr. Fiona Angrisano (PhD) 2014; Ms. Rachel Gillespie (MSc) 2014; Ms. Josie Ferreira (MSc) 2014; Mr. Javier Vinals Camallonga (MSc) 2014; Dr. Silvia Haase (Postdoc) 2014; Dr. Wilson Wong (Postdoc) 2014; Ms. Melanie Condron (Technician) 2014; Ms. Yan Hong Tan (Research Technician) 2014; Mr. Raphael Kim (Technician) 2014; Ms. Melanie Stockhausen (MSc) 2014; Ms. Grace Singh (Undergrad) 2014; Dr. Noa Dahan Pasternak (Visitor) 2013; Dr. Tim Satchwell (Visitor) 2013; Dr. Mark Scott (Visitor) 2013; Dr. Kartik Bane (Visitor) 2012; Dr. Ito Daisuke (Visitor) 2012; Dr. David Riglar (PhD) 2012; Mr. Danushka Marapana (Technician) 2012.