When nature makes a spelling mistake...

Sometimes a single letter change in a protein, a single amino acid change to be precise, can change your life. And I'm not talking about some horrible disease, I'm talking about something good! As a life long milk intolerant I've looked longingly at others consuming lattes, sipping hot chocolates, devouring various cheeses and having their pick of smoothies. Well no longer. And its all down to a single amino acid spelling mistake. It turns out that the milk protein, beta-Caesin comes in different forms. In regular cows milk theres a mixture of two types A1 and A2, the only difference between them being a histidine (H) amino acid at position 67 in the variant A1 substituted by proline (H) in

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For further information contact: jake.baum@imperial.ac.uk

(c)  Baum laboratory 2019